Allergies & Asthma

Individuals with a history of atopic disease, such as asthma and eczema (a.k.a. atopic dermatitis), are at significantly increased risk for developing osteoarthritis (OA), analysis of medical insurance claims indicated. With some 110,000 people with asthma or atopic dermatitis matched to the same number of individuals without these conditions, the odds of developing OA were
0 Comments
Enhanced treatment of atopic dermatitis with topical corticosteroids significantly reduced hen’s egg allergy compared with conventional reactive treatment in infants, but also resulted in adverse effects on growth, a randomized controlled trial in Japan showed. Among 640 infants ages 7 to 13 weeks, 31.4% of those who received enhanced treatment to clinically affected and unaffected
0 Comments
Long-term exposure to heat and cold from the second trimester to 4 weeks after birth was associated with lung function among female newborns, according to a French population-based cohort study. Specifically, long-term heat and cold exposure were associated with decreased functional residual capacity (FRC) and increased respiratory rate, while only long-term cold exposure was linked
0 Comments
Routine bronchoscopy may clarify the treatment pathways for patients suffering from severe uncontrolled asthma (SUA) who are being considered for biologic therapy indicated for a T2 inflammation phenotype, according to a prospective study. After receiving a bronchoscopy, a substantial number of people were found to have comorbidities aggravating asthma control: 21% had gastroesophageal reflux disease
0 Comments
Long-term exposure to ambient air pollution was associated with an increased risk of long COVID among young adults, according to a Swedish population-based cohort study. For each increase in interquartile range (IQR) in exposure to particulate matter ≤2.5 μm (PM2.5) in 2019 (median annual exposure 6.39 μg/m3), the odds of developing long COVID increased by
0 Comments
Use of leukotriene-receptor antagonists (LTRAs) during pregnancy was not associated with significant risks of neuropsychiatric events in offspring, according to a nationwide cohort study from Taiwan. Among the children of women with a diagnosis of asthma or allergic rhinitis during pregnancy, no significant associations were found between prenatal LTRA exposure and attention deficit-hyperactivity disorder (ADHD;
0 Comments
Intranasal corticosteroids (INCs) improved quality of life for children suffering from chronic rhinosinusitis, the RAISE randomized trial showed. Sinus and Nasal Quality of Life Survey (SN-5) scores improved significantly more for children assigned to daily intranasal mometasone spray (Nasonex) along with daily saline solution rinsing with a nasal nebulizer compared with the saline routine alone,
0 Comments
SAN ANTONIO — Treatment with the interleukin-5 (IL-5) antagonist mepolizumab (Nucala) increased freedom from oral corticosteroids after 2 years in patients with severe eosinophilic asthma, according to a post-hoc analysis of the real-world prospective REALITI-A trial. The proportion of those achieving freedom from oral corticosteroids increased from 4% at week 0 to 22% at week
0 Comments
SAN ANTONIO — Many reported anaphylactic reactions to COVID-19 vaccination may in fact be attributable to vaccine-induced immunization stress-related response (ISRR), suggested findings from a small study presented here. Cases of ISRR — a non-allergic condition that mimics many of the symptoms of anaphylaxis — may help explain why rare anaphylactic reactions to mRNA COVID
0 Comments
SAN ANTONIO — Peanut oral immunotherapy (OIT) at maintenance doses 10 times lower than conventional dosing may be an effective strategy for desensitizing peanut-allergic patients, according to findings from an ongoing study. Researchers from academic centers in Toronto and Montreal are randomizing peanut-allergic children to peanut avoidance, very low-dose OIT at a dosage of 30
0 Comments
SAN ANTONIO — Epicutaneous immunotherapy (EPIT) administered through an investigational skin patch over 12 months led to more responses — with favorable safety — compared with placebo in peanut-allergic toddlers with and without other food allergies or atopic dermatitis (AD), according to two subanalyses of the phase III EPITOPE trial. Among children ages 1 to
0 Comments
SAN ANTONIO — Among patients with hereditary angioedema (HAE), monthly injections of the investigational biologic garadacimab reduced the mean attack rate substantially in the phase III VANGUARD clinical trial. During the 6-month trial, the average monthly HAE attack rate dropped to 0.27 in the garadacimab group versus 2.01 for the placebo group (P<0.001), representing a
0 Comments
Peanut sublingual immunotherapy (SLIT) achieved clinically significant desensitization to peanut allergens in the majority of children in an open-label, prospective study. Among 47 kids who completed therapy and the 48-month double-blind, placebo-controlled food challenge, 70% achieved clinically significant desensitization (successfully consumed dose [SCD] >800 mg), and 36% achieved full desensitization (SCD 5,000 mg), reported Edwin
0 Comments
The five-question CAPTURE screening tool showed high specificity but low sensitivity in detecting undiagnosed chronic obstructive pulmonary disease (COPD) in primary care. Of 110 patients with undiagnosed but clinically significant COPD, 53 had a positive result on CAPTURE with a specificity of 88.6% (95% CI 87.6%-89.6%) and a sensitivity of 48.2% (95% CI 38.6%-57.9%), reported
0 Comments
Use of the population-based Hospital Frailty Risk Score (HFRS) may misclassify frailty in hospitalized patients with chronic obstructive pulmonary disease (COPD) exacerbation compared with use of the beside Clinical Frailty Scale (CFS), according to a cross-sectional study. Using the CFS as a criterion standard measurement, the HFRS had a sensitivity of 27% and a specificity
0 Comments