Clinical Trials & Research

When we eat food, our gut somehow senses its presence to begin shifting it along our digestive tract, but the question has always been – how? Now, new Flinders University research using both human gut samples and mice has discovered that a touch-sensing protein that was a focus of a 2021 Nobel Prize, called Piezo2,

In 2010, scientists discovered that African Americans who are born with certain variants of a gene called apolipoprotein L1 (APOL1) have a higher-than-average risk for experiencing chronic kidney disease (CKD). Now, in a new study of African Americans with hypertension, researchers at the Icahn School of Medicine at Mount Sinai find that a community-based approach

Women who were younger at the time of their first menstrual period (menarche) are more likely to report chronic pain in adulthood, reports a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal is published in the Lippincott portfolio by Wolters Kluwer. “We found strong associations

Thought LeadersDr. Gareth HollandsBehavioral ScientistUniversity College London In this interview, we speak to Dr. Gareth Hollands about his latest research that investigated the use of medical imaging to reduce health risks and encourage behavior change. Please can you introduce yourself, tell us about your background in health risk and behavioral change, and what inspired your

Fortis Life Sciences has acquired Abcore, a San Diego, California, USA based antibody discovery platform specializing in nanobody technology. With the addition of Abcore, Fortis extends its capabilities into the antibody discovery market serving biopharma customers developing antibody and nanobody-based therapeutics. Abcore is a powerful addition to the Fortis portfolio and deepens our antibody product

Hematopoietic stem cells (HSCs) have the capacity to both self-renew and differentiate into all mature blood cell types, making them promising treatments for a variety of diseases. However, the mechanisms involved in engraftment-;when the cells start to grow and make healthy blood cells after being transplanted into a patient-;are poorly understood. A recent study led

New research from the University of East Anglia (UEA) and Quadram Institute reveals how our immune system can be triggered to attack cancer cells. The research, published today in the Journal of Clinical Investigation, could help develop new approaches to treating people with leukemia. The team studied acute myeloid leukemia – a blood cancer which

People who are more physically fit are less likely to develop Alzheimer’s disease than people who are less physically fit, according to a preliminary study released today, February 27, 2022, that will be presented at the American Academy of Neurology’s 74th Annual Meeting being held in person in Seattle, April 2 to 7, 2022 and

Researchers are set to trial a non-invasive treatment for inoperable early-stage liver cancer, thanks to an injection of over $2 million in federal government funding. Led by Professor Alan Wigg from Flinders University’s College of Medicine and Public Health, the trial aims to test stereotactic ablative body radiotherapy (SABR), a non-invasive technique that enables high

The risk for postpartum depression is highest among first-time mothers, mothers younger than 25 years old and mothers of twins, according to a survey of more than 1.1 million moms worldwide. Image Credit: UVA Health Moms older than 40 years old having twins are at the highest risk, researchers from the University of Virginia School

In a recent peer-reviewed study, posted to the journal Geoscience Frontiers, researchers conducted a systematic meta-analysis on several studies that assessed the viral RNA load of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in effluents, sludge, and biosolids, and found that the prevalence of SARS-CoV-2 RNA is highest in sludge, followed by biosolids and

A pioneering new study led by UCL and National Institutes of Health (NIH) scientists has revealed, for the first time, why a common genetic variant worsens disease outcomes for people with the devastating adult-onset neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Published in Nature, the study shows how TDP-43 protein depletion, associated

In a recent study posted to the Research Square* pre-print server, a team of researchers from Italy and the United States (US) retrospectively reviewed and compared viral load in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and previous SARS-CoV-2 strain-induced infection. Short Report: SARS-CoV-2 Omicron infection is associated with high nasopharyngeal viral load. Image

In a recent study under consideration at Scientific Reports and posted to the Research Square* preprint server, researchers evaluated the impact of time on the sensitivity of four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays using samples from the coronavirus disease 2019 (COVID-19) staff testing of antibody responses study (Co-Stars) in the United Kingdom

Northwestern University behavioral scientist Linda Teplin will present research on Saturday, Feb. 19 from her groundbreaking Northwestern Juvenile Project at the upcoming 2022 annual meeting of the American Association for the Advancement of Science (AAAS). The meeting, “Empower with Evidence,” will take place online Feb. 17-20. For information about media registration, email [email protected] and include

The closure of a gate at a national wildlife refuge in Denver about a decade ago ensured protection for bison, bald eagles and other wildlife inside, but also created a physical and metaphorical barrier for people living in diverse communities just outside the fence. The case of the fence and closed gate surfaced during public

Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, similar to the non-communicable diseases cancer, obesity, cardiovascular disease and diabetes. In a review article in The Lancet Diabetes & Endocrinology, Norbert Stefan and Kenneth Cusi first highlight the extent to which NAFLD and diabetes jointly occur worldwide. Then they address the major mechanisms that are

Celebrating a 75-year legacy in centrifugation, Beckman Coulter Life Sciences launches its most versatile 3-liter benchtop centrifuge yet – the Allegra V-15R refrigerated centrifuge. Featuring 10 rotor configurations and 50 programmable runs along with a comprehensive selection of adapters, a variety of workflows and applications can be performed – from cell and blood separation to

Vaccine hesitancy refers to delay in accepting or refusing immunization services despite their availability. It is a complicated and context-dependent phenomenon that varies with time, place, and vaccines. Vaccine hesitancy might compromise herd immunity and have an adverse effect on vaccine campaigns. The COVID-19 pandemic has been followed by a massive infodemic – a flood of information,

In a recent study posted to the medRxiv* preprint server, researchers evaluated the cross-reactivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-triggered neutralization and fragment crystallizable (Fc) effector functions between coronavirus disease 2019 (COVID-19)-vaccinated and unvaccinated individuals in South Africa. Study: SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but

Combining centuries-old traditional mandala coloring with cutting-edge computing and brain sensing technologies could lead to new ways of helping people achieve mindfulness. Mandalas are geometric configurations of shapes that have their origins in Buddhist traditions. The coloring of mandala shapes is increasingly popular as a way for people to attempt ‘mindfulness’, a way of being

In a recent study posted to the medRxiv* pre-print server, researchers used a suite of methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the testis of patients who died from coronavirus disease 2019 (COVID-19) to gain insights into SARS-CoV-2 tropism inside testis and its impact on male fertility. Human testis cells express

It has long been known that there is an association between food and pain, as people with chronic pain often struggle with their weight. Researchers at the Del Monte Institute for Neuroscience may have found an explanation in a new study that suggests that circuitry in the brain responsible for motivation and pleasure is impacted

The sign and symptoms of the acute sequelae of post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may persist beyond 30 days after the infection. The post-acute sequelae or long coronavirus disease (COVID) can affect multiple organ systems. Thus, the natural course of the sequelae post-COVID must be accurately defined. Besides, the severity of

Despite the perception that marijuana is harmless, there is some scientific evidence challenging that belief, and there are many unanswered questions about its impact on brain health, according to a new American Heart Association scientific statement published today in the Association’s journal Stroke. This scientific statement will be presented and discussed during a symposium at

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, is a highly pathogenic coronavirus belonging to the betacoronavirus genus. The genome of SARS-CoV-2 consists of a single-stranded RNA of 29,903 nucleotides. SARS-CoV-2 is associated with a very high mutation rate, and, recently, machine learning has proved to

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory. The

In a recent Science Journal research paper, researchers identify 17 individuals who were infected with a highly virulent variant of the human immunodeficiency virus 1 (HIV-1). Study: A highly virulent variant of HIV-1 circulating in the Netherlands. Image Credit: Federov Oleksiy / Shutterstock.com Background Related Stories Ribonucleic acid (RNA) viruses like the severe acute respiratory syndrome coronavirus