Clinical Trials & Research

Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza. The team led by Prof. Hiroki Kato from the Institute of Cardiovascular Immunology at the University Hospital Bonn has

NEW YORK, Feb. 8, 2023. Hoth Therapeutics, Inc., a patient-focused biopharmaceutical company, today announced proof-of-concept data generated using cognitive and behavioral assessments in an Alzheimer’s disease mouse model (aged APP/PS1+/- mice), supporting the therapeutic cognitive potential of HT-ALZ after chronic oral dosing of 20mg/kg and 40mg/kg of HT-ALZ The research was conducted as part of

A national study on access to healthcare visits, medicine/medical equipment and community resources during the COVID-19 pandemic, shows disparities related to sociodemographic characteristics, like race, gender, and age. The study also reveals disparities connected to health-related characteristics, such as having a chronic illness, a mental health condition, or a disability. A detailed analysis of data

MELBOURNE, Australia, Feb. 6, 2023. Certa Therapeutics (Certa) today announces ground-breaking clinical trial data for FT011, its novel therapy for the treatment of serious inflammatory and fibrotic diseases. Certa has recently completed a global Phase 2, multi-centre, randomised, double blind, placebo-controlled study of the pharmacokinetics, pharmacodynamic effects, and safety, of oral FT011 in patients with

Virus Watch was funded by The United Kingdom Research and Innovation (UKRI) Medical Research Council (MRC) & the Department of Health and Social Care National Institute for Health and Care Research (DHSC NIHR) in April 2020 under the COVID-19 Rapid Response Call 2. The motive behind Virus Watch was to bring together an experienced team

CARLSBAD, Calif., Feb. 1, 2023. Ionis Pharmaceuticals, Inc. today announced that GSK has initiated two randomized, double-blind, placebo-controlled Phase 3 studies evaluating the safety and efficacy of bepirovirsen (formerly IONIS-HBVRx), an investigational antisense medicine for the treatment of patients with chronic hepatitis B infection (CHB). “The initiation of this Phase 3 program is an important

A team of researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Massachusetts General Hospital (MGH) has developed a soft robotic wearable capable of significantly assisting upper arm and shoulder movement in people with ALS. Some 30,000 people in the U.S. are affected by amyotrophic lateral sclerosis (ALS), also

SEATTLE and BRISBANE, Australia, Feb. 2, 2023. Immunexpress, Pty Ltd., a molecular diagnostic company focused on improving outcomes for suspected sepsis patients, announced today the publication of a study in Scientific Reports, a journal in the Nature portfolio, validating the use of SeptiCyte RAPID as a triaging tool for COVID-19 patients requiring hospitalization and potentially

New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness. Many people are unaware that some antidepressants (medications used to treat people living with depression) are also being prescribed to treat certain chronic pain conditions. Chronic pain affects between one-third and one-half

SAN DIEGO and TORONTO, Jan. 30, 2023. Aptose Biosciences Inc. (“Aptose”) today announced the 120 mg monotherapy dosing of patients in the APTIVATE Phase 1/2 clinical trial of tuspetinib (formerly HM43239), an oral, mutation agnostic tyrosine kinase inhibitor (TKI) being developed for the treatment of patients with relapsed or refractory acute myeloid leukemia (R/R AML).

Testing plays a crucial role in humanity’s strategy to mitigate the effects of widespread COVID-19 infection. However, given multiple options for testing and the emergence of the highly contagious Omicron variant, how do we choose which test to use? A study led by Osaka University recently found that the sensitivity of rapid antigen tests (RATs)

Anesthesiologists can play a role in reducing the greenhouse gas emissions that contribute to global warming by decreasing the amount of anesthetic gas provided during procedures without compromising patient care, suggests new research being presented at the American Society of Anesthesiologists’ ADVANCE 2023, the Anesthesiology Business Event. Inhaled anesthetics used during general anesthesia are estimated

Are you looking to accelerate your liquid handling protocols? To combat the issue of tedious volume adjustments, look no further than EVOLVE manual pipettes! INTEGRA Biosciences is giving away 15 EVOLVE starter packs in an exciting prize draw. Choose your ideal pipette size – covering a range of volumes from 0.2 µl to 5000 µl

Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years. In the study, appearing Jan. 27,

Two novel research studies from Cedars-Sinai move the needle on predicting two important heart conditions-; sudden cardiac arrest, which is often fatal, and increased coronary artery calcium, a marker of coronary artery disease that can lead to a heart attack. The studies were led by investigators in the Smidt Heart Institute at Cedars-Sinai and the

Obesity is linked to many adverse health outcomes, including in pregnancy. However, there is little information on the effect of maternal obesity on neonatal mortality and illness. A recent study published in the American Journal of Obstetrics & Gynecology Maternal-Fetal Medicine discusses the association of maternal body mass index (BMI) in pregnancy with neonatal outcomes.

It’s clear that chronic stress can impact our behavior, leading to problems like depression, reduced interest in things that previously brought us pleasure, even PTSD. Now scientists have evidence that a group of neurons in a bow-shaped portion of the brain become hyperactive after chronic exposure to stress. When these POMC neurons become super active,

Indigenous populations, including people of American Indian and Alaska Native origin, are underrepresented in clinical trials. Researchers collaborated to modify the “trust triangle” model used in clinical trial recruitment and expanded it to a new model called, “The Trust Circle.” This new model takes into account the various entities that are part of the recruitment

A four-drug chemotherapy regimen provided longer overall survival than a two-drug combination in a Phase 3 clinical trial for metastatic pancreatic ductal adenocarcinoma. The study is believed to be the first metastatic pancreatic cancer study in nearly a decade to have a positive endpoint for overall survival. Dr. Zev Wainberg, co-director of the UCLA Health

Pulmonary arterial hypertension (PAH) is a rare and incurable disease of the lung arteries that causes early death. In PAH, excess scar tissue and thickening of lung blood vessels occur as the result of increased cell “biomass.” These changes obstruct blood flow and are detrimental to the heart, but until now the basic features of

Contrary to popular belief, rest may not always be the best cure after a concussion, new study published in JAMA Network Open finds. In fact, an early return to school may be associated with a lower symptom burden after suffering a concussion and, ultimately, faster recovery. “We know that absence from school can be detrimental

Scientists have discovered a protein that kick-starts milk production after breastfeeding is over – something which could provide effective new targets for cancer treatments. The groundbreaking study from the University of Sheffield uncovered a protein called Rac1, which acts as a critical switch to kick-start milk production in breast cells when lactation has stopped and

Asthma and obesity are common inflammatory diseases that are mediated by specific immunological features. For example, asthma is associated with Th2 response, while obesity is with the Th1/Th17 profile. When these immunological features are combined, more severe asthmatic reactions occur with greater frequency. Recently, alterations in the immunological features, in relation to obesity and asthma,

Previous studies have described the importance of analyzing dietary patterns, rather than analyzing the nutritional content of individual food products, to better understand overall dietary quality, promote better health status, and ultimately mitigate disease risk. A recent Clinical Nutrition study identifies blood metabolomic markers and metabolite panels linked to the Mediterranean diet in pregnant women.  Study: Metabolomic biomarkers

To determine the representation of women among scientific journal editors -; key players in the scientific community who have the final say about what papers get published -; a team led by NYU Abu Dhabi (NYUAD) researchers has completed the largest study to date of systemic gender inequality in editorial boards over the past five

A randomized controlled trial conducted on elderly individuals shows that an improvement in physical fitness and cognition can be achieved by increasing daily physical activity to a certain level. The trial findings are published in the journal Alzheimer’s Research & Therapy. Study: The effects of a moderate physical activity intervention on physical fitness and cognition

As humans, we each have trillions of cells. And each cell has a nucleus with individual genetic information –DNA – that can mutate to create an abnormality. If a human is born with an abundance of abnormalities within cells, or if mutations develop over time, disease ensues. To make this even more complicated, cells are

When genes are activated and expressed, they show patterns in cells that are similar in type and function across tissues and organs. Discovering these patterns improves our understanding of cells -; which has implications for unveiling disease mechanisms. The advent of spatial transcriptomics technologies has allowed researchers to observe gene expression in their spatial context