Clinical Trials & Research

Researchers at La Jolla Institute for Immunology (LJI) have at last uncovered how an enzyme called O-GlcNAc transferase (OGT) keeps cells healthy. Their findings, published in the Proceedings of the National Academies of Sciences, reveals a key aspect of cellular biology and may lead to important medical advances. Many diseases are related to OGT function.

Severe inflammation weakens the body’s ability to kill cancerous blood cells in people with acute myeloid leukemia (AML), a new study shows. Experiments in human cells also revealed how increasing levels of inflammation, marked by an aggressive reaction of immune cells in the bone marrow, altered the makeup of immune B cells and T cells

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health found that older adults with greater severity of hearing loss were more likely to have dementia, but the likelihood of dementia was lower among hearing aid users compared to non-users. The findings, from a nationally representative sample of more than

In a recent study posted to the medRxiv* preprint server, researchers performed a genomic assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant’s BA.1 subvariant transmission in England. Study: Genomic assessment of invasion dynamics of SARS-CoV-2 Omicron BA.1. Image Credit: PHOTOCREO Michal Bednarek/Shutterstock Background The swift upsurge in coronavirus disease 2019 (COVID-19) case

As more U.S. states legalize cannabis (also known as marijuana) for medical and recreational use, increasing numbers of people are experimenting with it for pain relief. According to a new study published in JAMA Network Open, almost a third of patients with chronic pain reported using cannabis to manage it. Related Stories More than half

Get more exercise. Eat right. Make new friends. As we compile our lists of resolutions aimed at improving physical and mental health in 2023, new CU Boulder research suggests one addition could have a powerful impact: Gardening. Funded by the American Cancer Society, the first-ever, randomized, controlled trial of community gardening found that those who

There has been an increase in the development of coronavirus disease 2019 (COVID-19) vaccines in several countries due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The RNA vaccine platform is a next-generation platform that comprises messenger RNA (mRNA), which helps to encode the target antigen. The first concept of an

Long COVID has emerged as a pandemic within the pandemic. As scientists work to untangle the many remaining unanswered questions about how the initial infection impacts the body, they must now also investigate why some people develop debilitating, chronic symptoms that last months to years longer. A new machine learning tool is here to help.

A recent study published in Preventive Medicine found that messaging campaigns discouraging the consumption of unhealthy beverages were more promising than those promoting healthy drinks among parents in the United States (US). Study: Should messages discourage sugary drinks, encourage water, or both? A randomized experiment with U.S. parents. Image Credit: WS-Studio/Shutterstock Background Related Stories Overconsumption

A rapidly growing body of evidence shows the importance and effectiveness of cognitive rehabilitation for individuals with traumatic brain injury (TBI). A major update of the groundbreaking INCOG guidelines for cognitive rehabilitation following TBI is presented in the January/February special issue of the Journal of Head Trauma Rehabilitation (JHTR). The official journal of the Brain

Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to innovations in expansion microscopy. The advancements could help provide future insight into neuroscience, pathology, and many other biological and medical fields. In the paper “Magnify is a universal molecular anchoring strategy for expansion microscopy,” published Jan. 2 in the

Millions more patients across England are benefitting from easier access to their health records and medical services through the NHS App, as sign ups top 30 million – including seven million new sign ups in 2022. The app, which launched four years ago, was one of the most popular free health apps of 2022 –

In cancer patients with neutropenic fever, delaying antibiotic treatment past 60 minutes from the time of fever detection does not reduce the short-term chance of survival, according to a study in the American Journal of Medical Quality. The journal is published in the Lippincott portfolio by Wolters Kluwer. Neutropenia-;low levels of white blood cells called

Dr. Niklas Klümper, resident at the Clinic for Urology and working group leader at the Institute for Experimental Oncology at the University Hospital Bonn (UKB), was awarded the C. E. Alken Prize in recognition of his outstanding scientific uro-oncological work. The 30 -year-old is investigating which patients with metastatic bladder cancer benefit from a new

Between the time you read the Wi-Fi password off the café’s menu board and the time you can get back to your laptop to enter it, you have to hold it in mind. If you’ve ever wondered how your brain does that, you are asking a question about working memory that has researchers have strived

Probiotic-based therapeutic approaches are relatively new to the field of clinical dentistry. According to a recent review published in Frontiers in Dental Medicine, probiotic-based therapy in conjunction with established treatment regimens can effectively combat gingivitis and periodontitis. Study: Probiotics in the Management of Gingivitis and Periodontitis. A Review. Image Credit: Lightspring/Shutterstock Oral microbiome  The human microbiome consists

Type 2 diabetes mellitus is a common lifestyle disease that is prevalent worldwide. It can often lead to complications, such as diseases of the heart, and increased risk of death, but preventive measures, such as a healthy diet, can reduce these risks. Now, a study in Japan has shown that xanthan gum-based fluid thickener can

New research from the University of Copenhagen suggests that a portion of the Danish population has a composition of gut microbes that, on average, extracts more energy from food than the microbes in their fellow Danes’ guts. The research is a step towards understanding why some people gain more weight than others, even when they

A team from the Universitat Politècnica de València (UPV), the Universitat de València (UV), and the Centro de Investigación Biomédica en Red sobre Enfermedades Raras (CIBERER) has developed a lateral flow test that identifies and quantifies the level of allergens reliably in food with the help of a smartphone. The work has been published in

A study published in the Journal of the American Heart Association describes that excessive consumption of coffee can increase the risk of cardiovascular disease-related mortality in individuals with severe hypertension. Study: Coffee and Green Tea Consumption and Cardiovascular Disease Mortality Among People With and Without Hypertension. Image Credit: Bohdan Malitskiy / Shutterstock Background Consumption of coffee is

A team of researchers from Brown University’s School of Public Health, Brown’s School of Engineering and Silent Spring Institute found that simple air filtration devices called Corsi-Rosenthal boxes are effective at reducing indoor air pollutants. The study, which analyzed the effectiveness of Corsi-Rosenthal boxes installed at the School of Public Health to help prevent the

Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor. This is according to a new study published in Cancer Immunology Research by researchers at Karolinska Institutet in Sweden. Treatments for various forms of cancer

Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But what prevents neurons and vascular cells from getting in each other’s way as they grow? Researchers at the Universities of Heidelberg and Bonn, together

New research from The University of Warwick has revealed that orangutans, the most arboreal of the great apes, produce consonant-like calls more often and of greater variety than their African ground-dwelling cousins (gorillas, bonobos and chimpanzees). This contrasts with the expectation that, whilst being closely related to humans, African apes should have call repertoires which

Psychosocial stress is associated with an increased risk of stroke, according to new University of Galway led research published in the Journal of the American Medical Association Network Open (JAMA Network Open). The research found that the occurrence of any stressful life event increased the risk of stroke by 17%, with the occurrence of two

Lipstick can be a confidence booster, enhance a costume and keep lips from chapping. But sharing a tube with a friend or family member can also spread infections. To develop a version with antimicrobial properties, researchers reporting in ACS Applied Materials & Interfaces have added cranberry extract to the formulation. Their deep red cream quickly

In a recent article published in JAMA Network Open, researchers conducted a retrospective, multisite cohort study among 11 to 17-year-old adolescents in the United States of America (USA) and France. They assessed the month-on-month change in the number of mental health condition–related hospitalizations between pre- and post-pandemic times. Study: Hospitalizations Associated With Mental Health Conditions Among

Sponsored Content by Verogen, Inc.Dec 16 2022Reviewed by Louis Castel insights from industryAlexis GarloffResearch AssistantTowson University Next-generation sequencing (NGS) can aid law enforcement in solving decades-old cases and provide justice for victims. There is a higher chance of finding a perpetrator when NGS data is used, as opposed to the traditional DNA profile. In this