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NEW ORLEANS ­— Two patients with type 1 diabetes have now experienced improved blood glucose control with Vertex Pharmaceutical’s investigational allogeneic stem-cell derived islets (VX-880), with the first person now completely insulin-independent at 9 months post-transplant. Prior to the procedure, both patients had hypoglycemic unawareness and had experienced multiple episodes of severe hypoglycemia, conditions considered

Working the night shift can be particularly arduous and even dangerous for workers like doctors and nurses. They need to take 20-minute power naps, according to an expert who will discuss such naps’ importance for the safety of health workers and their patients. Sleep isn’t just a time of rest as it is an “essential“ part of people’s overall

High-dose ifosfamide has shown superior survival benefit over three other chemotherapy regimens for patients with recurring or refractory primary Ewing sarcoma (RR-ES) in the practice-changing rEECur trial. This international trial is the first randomized head-to-head comparison of commonly used chemotherapy regimens in patients with the rare and deadly disease. The study results are expected to

CHARLOTTE, N.C. — Positive airway pressure (PAP) machines were helpful enough that pediatric patients could have symptoms improve even without being compliant, according to researchers advocating for greater access to this therapy for this population. At one center’s sleep clinic, 172 out of 221 children with obstructive sleep apnea (OSA) reported improved symptoms approximately 3

New results from a trial in patients with newly diagnosed multiple myeloma offer some answers to questions about which treatment route to choose. The trial, known as DETERMINATION, found that newly diagnosed patients treated with a triplet of drugs had longer progression-free survival (PFS) if they received an autologous stem cell transplant (ASCT) soon after

The investigational insulin-only iLet Bionic Pancreas (Beta Bionics) reduced A1c without increasing hypoglycemia in adults and children with type 1 diabetes with greater automation than currently available hybrid closed-loop or artificial pancreas insulin delivery systems. Results from the pivotal multicenter Insulin-Only Bionic Pancreas Pivotal Trial were presented during a 1-hour symposium on June 3 at

CHICAGO — Randomized data suggest that an anti-angiogenic agent can kick-start immunotherapy’s antitumor activity in non-small cell lung cancer (NSCLC) patients whose disease has already progressed after chemotherapy and a checkpoint inhibitor. In the phase II study, median overall survival improved by nearly 3 months with ramucirumab (Cyramza) plus pembrolizumab (Keytruda) versus standard-of-care options (14.5

Treatment of people with obesity but no diabetes with the dual incretin agonist tirzepatide safely produced “unprecedented” levels of weight loss in the vast majority of patients in SURMOUNT-1, a placebo-controlled trial with more than 2500 people with obesity or overweight plus at least one weight-related complication. Although the pivotal trial did not directly compare

At least two strains of monkeypox are currently circulating in the United States, officials from the Centers for Disease Control and Prevention (CDC) said Friday. Most cases in the United States involve the same strain that has been spreading in the United Kingdom and Europe, but investigators have also detected a variant. This could mean

CHICAGO — More than 40% of patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC) responded to treatment with adagrasib, findings from a phase II trial showed. Among 112 evaluable patients in the KRYSTAL-1 study, all of whom were previously treated, the confirmed objective response rate (ORR) was 42.9% with the investigational KRAS G12C inhibitor,

Trauma surgeons are in the tough position of seeing victims just after gun violence across the United States, and they have some advice. Their strategies can work regardless of where you stand on the Second Amendment of the Constitution, said Patricia Turner, MD. “Our proposals are embraced by both gun owners and non-gun owners alike,

Pfizer’s COVID-19 vaccine became available for children aged five to 11 in the UK in April 2022. Those aged 12 and up had already been eligible since 2021. But if you have a child aged under five, you might be wondering, when will they be able to be vaccinated against COVID-19? Children under five represent

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The FDA has accepted Pfizer’s application for a COVID-19 vaccine for children under age 5, which clears the way for approval and distribution in June. Pfizer announced Wednesday that it completed the application for a three-dose vaccine for kids between 6

Several months ago, I wrote a post on a Facebook community of over 17,000 Black physicians. The post asked them what they would do and how they would react if their child told them they were gay. The responses I received ranged from “I will love and accept them” to “Heaven forbid!” to “I will

A long-standing request to clarify data irregularities in a 2021 ISCHEMIA substudy resulted in the publication of one correction, with a second correction in the works. Further, the lone cardiac surgeon on the ISCHEMIA trial steering committee, T. Bruce Ferguson, MD, has resigned from the committee, citing a series of factors including an inability to reconcile

COPENHAGEN — The Janus kinase (JAK) inhibitor upadacitinib (Rinvoq, AbbVie) was associated with significant improvements in disease activity, pain, function, and quality of life compared with placebo in patients with nonradiographic axial spondyloarthritis (nr-axSpA), results of the first efficacy analysis of the phase 3 randomized SELECT-AXIS-2 trial showed. The trial met its primary endpoint of

During an interview with David Letterman for his Netflix series, “My Next Guest Needs No Introduction,” singer Billie Eilish made a sudden movement, whipping her head around and opening her mouth. Letterman asked her what was going on — was it the fly that had been flying around them earlier? “No. I’m ticcing,” she said.

The COVID-19 pandemic has challenged the academic and psychological stability of medical students, leading to high rates of burnout. Researchers surveyed 613 medical students representing all years of a medical program during the last week of the Spring semester of 2021. Based on the Maslach Burnout Inventory-Student Survey (MBI- SS), more than half (54%) of

You may have a sniffly child under two years old at home. Is it just a cold? Or could it be COVID? You may be tempted to reach into the cupboard for a rapid antigen test to find out. But some manufacturers say their COVID tests aren’t suitable for children under two. Can you use

Successful aging is something that most of us strive for. But with aging comes a pervasive condition called fatigue that, in many older adults, interferes with everyday functioning, mental health, social support, and overall quality of life. The relationship between fatigue and cognitive and functional impairment is one of particular interest in people living with HIV

CHICAGO — Overall survival (OS) in Black patients with cancer improved significantly, and racial disparities in cancer survival decreased, with increased state-level spending on public welfare programs, a large retrospective review showed. Every 10% increase in public welfare spending was associated with an 8.6% improvement in cancer survival among Black patients, almost four times greater

The World Health Organization (WHO) has seemingly assured the public that there’s nothing to worry about the monkeypox outbreak causing another global health crisis amid the COVID-19 pandemic.  On Monday, an official from the specialized agency maintained that it’s unlikely for the monkeypox outbreak outside Africa to lead to another pandemic, Reuters reported.   As

Headache medicine expert Joel Saper, MD once saw the formation of the United Council for Neurologic Subspecialties as a sign of progress in the field. In 2005, he even helped write their first certification exam for headache medicine. Dr Joel Saper Now he’s calling fraud. After Saper’s initial 10-year certification expired, he paid $1,800 to

The U.S. Food and Drug Administration granted emergency use authorization to AstraZeneca’s COVID-19 antibody drug Evusheld on Dec. 8, 2021. Infectious disease physician Patrick Jackson of the University of Virginia explains how it works, who’s eligible and why some patients are having difficulties accessing it. 1. What is Evusheld, and how does it work? Evusheld

Immunotherapy with nivolumab (Opdivo) is now approved in the United States for first-line use in the treatment of unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC). The new approval for the drug, a programmed cell death ligand-1 (PD-L1) inhibitor, is for use in this patient population regardless of PD-L1 status. the indication also specifies

Drinking a few cups of coffee a day — even with sugar — was linked to a lower risk of death, new research showed. People who drank a moderate amount of coffee every day, either plain or sweetened with around a teaspoon of sugar, were about 30% less likely to die from any cause during

The transmissions of the monkeypox virus have been growing in number since the global outbreak started. The World Health Organization (WHO) reported 257 confirmed cases in its latest update on the situation.  On Sunday, the WHO released a new update detailing that there are now 257 confirmed monkeypox cases and around 120 suspected cases in

Time-restricted eating reduced cardiovascular risk among older breast cancer survivors, a single-group feasibility study suggests. The results show a 15% relative decline in cardiovascular risk, measured using the Framingham Risk Score, among at-risk breast cancer survivors (BCS) after only 8 weeks of following a time-restricted eating regimen, reported Amy A. Kirkham, PhD, assistant professor of kinesiology and