SAN FRANCISCO, Sept. 3, 2021. Quantum Leap Healthcare Collaborative, the sponsor of the I-SPY COVID Trial, today announced that the Famotidine Celecoxib arm has been dropped from the trial due to futility, based on the low likelihood of success. The Famotidine Celecoxib combination was chosen for testing because of their anti-histamine and anti-inflammatory mechanism of
Month: September 2021
Licensing productive transcription through RNA polymerase II stabilityPlay Video Credit: Northwestern University Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template, according to findings published in Molecular Cell. According to the study, the presence of a protein called SPT5 serves as a “passport,” determining
As dog owners, we often think our dogs truly understand us. And it turns out, science thinks you’re right too From the adorable head tilt to the excitable bark, our furry friends have long shown their abilities to understand human behaviour. And researchers have now discovered fresh data that suggests dogs are far savvier than
Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. A large, real-world test of face masks in Bangladesh shows that masks work to reduce community spread of COVID-19. It also shows that surgical masks are more effective than cloth face coverings. The study, which was published ahead of peer review,
This summer, deadly heatwaves over the US and Canadian Pacific Northwest claimed the lives of more than 100 people, many of them seniors over 70. In Washington state alone, the early summer heat wave killed more than 100 people, making it the deadliest weather-related event in the state’s history. And while the calendar has just
Treatment for Bacterial Vaginosis Daré Bioscience Announces FDA Acceptance and Priority Review of New Drug Application for DARE-BV1 for the Treatment of Bacterial Vaginosis SAN DIEGO, Aug. 09, 2021 (GLOBE NEWSWIRE) — Daré Bioscience, Inc. (NASDAQ: DARE), a leader in women’s health innovation, today announced that the U.S. Food and Drug Administration (FDA) accepted for filing
FDA Approves Trudhesa (dihydroergotamine mesylate) Nasal Spray for the Acute Treatment of Migraine SEATTLE, Sept. 03, 2021 (GLOBE NEWSWIRE) — Impel NeuroPharma, Inc. (NASDAQ: IMPL), a commercial-stage biopharmaceutical company developing transformative therapies for people suffering from diseases with high unmet medical needs, with an initial focus on the central nervous system, today announced that the
Could group therapy be right for you? Here’s what really goes on during sessions Doing what it says on the tin, group therapy is a psychological therapy that takes place in a group setting, rather than one-to-one. Available on the NHS and privately, these sessions bring together people with similar problems, to create a supportive,
From face masks to hand sanitizers and disinfecting sprays, there’s no shortage of “essential items” that are being marketed as able to help protect us from COVID-19. According to experts, another item that people should add to their list of essentials is an air purifier. The best air purifiers can help a lot in eliminating dust, pollen, smoke and other
Greater short-term variability in systolic blood pressure after intracerebral hemorrhage (ICH) is associated with an increased risk for long-term disability, new research suggests. A pooled analysis of randomized controlled trials indicated that each 10 mmHg increase in standard deviation of systolic blood pressure variability was associated with an 18% increase in the likelihood of functional
Fabiola Gianotti, the director-general of scientific research center CERN, told CNBC that she fears that science could largely be forgotten following the coronavirus pandemic. “Of course there is a danger, the danger that once the crisis [is] over science is put back into its little box or in a drawer to be taken out again
An FDA advisory committee offered up lower vector doses, stricter exclusion criteria, and long-term animal studies to grapple with liver toxicities associated with adeno-associated virus (AAV) vector-based gene therapies. During the second of four sessions on AAV safety, the Cellular, Tissue, and Gene Therapies Advisory Committee (CTGTAC) weighed evidence of hepatotoxicity — ranging from liver
I know we featured watermelon salad last week, but it is just so good right now! I stumbled upon this recipe for watermelon fruit pizza, a healthy-ish take on more traditional fruit pizzas that have a cookie crust. This one uses the watermelon as the “crust” and is topped with a creamy yogurt mixture and
Don and Karen Cohn have given $2.5 million to create the Don and Karen Cohn Chancellor’s Endowed Chair in Neurosurgery at University of California San Diego School of Medicine. The gift will support excellence in research, education and clinical care in the field of neurological surgery. Alexander Khalessi, MD, neurosurgeon at UC San Diego Health,
If you’re agonizing over the long hours tweens and teens spend scrolling through and posting to Instagram, TikTok, Snapchat and other social media sharing and messaging platforms, new UC Berkeley research has some enlightening news to share. When it comes to screen time, the problem is not so much the number of hours they spend
Here’s another likely health impact from climate change to add to the ever-growing list: more frequent chronic obstructive pulmonary disease (COPD) exacerbations. Each 1°C increment in outdoor temperature, after adjustment for humidity levels, was associated with a 2% increase in odds that COPD patients would experience exacerbations 2 days later (P=0.002), reported Supaksh Gupta, MD,
Victoria struggled with self-harm and an eating disorder for years. But with the help of a strong support system, she learned to live alongside her depression, and a new hobby ignited a sense of hope for the future Content warning: this piece include details of self-harm I will never forget the very first time I
Because of the COVID-19 epidemic, most U.S. healthcare systems were compelled to swiftly shift to virtual care in order to accommodate patients. However, now that most facilities have opened to the public, the focus has mainly switched back to in-person treatment. This means health systems are now faced with the task of further developing and
Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Top federal health officials have told White House officials that the plan to offer COVID-19 booster shots later this month may need to be limited at first, according to The New York Times . FDA and CDC leaders said that third
tapinarof Treatment for Plaque Psoriasis, Atopic Dermatitis Dermavant Announces FDA Acceptance for Filing of New Drug Application (NDA) for Tapinarof Cream for the Treatment of Adults with Plaque Psoriasis LONG BEACH, Calif. & BASEL, Switzerland–(BUSINESS WIRE) August 10, 2021 –Dermavant Sciences, a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology, today
CAMBRIDGE, Mass. & BEIJING, September 01, 2021–(BUSINESS WIRE)–BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160), a global biotechnology company focused on developing and commercializing innovative medicines worldwide, today announced that Brukinsa (zanubrutinib) has received approval from the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with Waldenström’s macroglobulinemia (WM). “We are delighted by
There is a real need for more tailored therapies for young people with cancer. For this year’s Childhood Cancer Awareness Month, clinician scientist Dr Sally George tells us about her work on neuroblastoma and why childhood cancers really do need specific research to develop the most effective treatments. Despite the differences in disease biology, children
A report has found that the rates of suicide in England and Wales dropped ‘significantly’ in 2020, but is that the full story? Content warning: this article contains a discussion on the topic of suicide. A new report, released 2 September 2021, from the Office for National Statistics, has found a ‘statistically significant’ decrease in
Prisons and jails have hosted some of the largest COVID-19 outbreaks in the U.S., with some facilities approaching 4,000 cases. In the U.S., which has some of the highest COVID-19 infection rates in the world, 9 in 100 people have had the virus; in U.S. prisons, the rate is 34 out of 100. I study
In patients with moderate to severe ulcerative colitis (UC), treatment with vedolizumab leads to better histologic outcomes than treatment with adalimumab, according to findings from the VARSITY trial. The findings come from an analysis in Gastroenterology of prespecified histologic exploratory endpoints from the phase 3, multicenter, randomized, controlled VARSITY trial, which was the first head-to-head comparison of
A woman walks along a bridge, as the Marina Bay Sands hotel and resort is seen in the background, in Singapore on August 16, 2021. Roslan Rahman | AFP | Getty Images SINGAPORE — Singapore is introducing booster Covid vaccine shots for people aged 60 and over, residents of nursing homes and those with suppressed immune
WASHINGTON — COVID booster shots are showing good efficacy in Israel, Anthony Fauci, MD, chief medical advisor to President Biden, said Thursday at a briefing held by the White House COVID-19 Response Team. Researchers have found that, even with the country’s very high vaccination rate, “we see new PCR-positive infections and new severe COVID cases
MANHASSET, N.Y., Sept. 2, 2021. As part of a new National Institutes of Health (NIH) coronavirus disease 2019 (COVID-19) vaccine clinical trial, The Feinstein Institutes for Medical Research – the science arm of Northwell Health – delivered its first set of extra shots to eligible New York patients with an autoimmune disease. An estimated 8