Month: September 2021

The investigational oral, neuroactive, steroid-positive allosteric modulator SAGE-324/BIIB124 (SAGE-324) is effective for treating essential tremor ― but problems with tolerability may limit its usefulness, new research suggests. The phase 2 KINETIC trial (NCT04305275) involved patients with essential tremor. Among patients treated with SAGE-324 for 28 days, there was a statistically significant reduction in upper-limb tremors
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Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder (NDD), according to a study published in the American Journal of Human Genetics. These findings add two new genetic variants to a growing list of glutamate receptor mutations that can cause neurodevelopmental disorders, according to Geoffrey Swanson, PhD, professor
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. CDC Director Rochelle Walensky, MD, late Thursday overruled her agency’s advisory panel to make boosters available to front-line workers. But unless the unvaccinated get their shots, the extra protection will not be enough, she said at a Friday briefing. The CDC’s
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The Mayo Clinic Center for Regenerative Medicine is accelerating the natural healing process to restore health and function to damaged tissue and organs. This video shows several examples of regenerative medicine and surgery clinical trials and studies that span the spectrum of diseases. The spectrum of clinical trial underscores the multidisciplinary nature of the Center
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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Katalin Kariko, PhD, a senior vice president at BioNTech, and Drew Weissman, MD, PhD, a professor in vaccine research at the University of Pennsylvania, Philadelphia, Pennsylvania, made a breakthrough discovery by modifying messenger RNA (mRNA), which provides instructions to cells to
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A 2013 study by Pérez et al. reported a very high accumulation of the industrial chemical perfluorobutanoic acid (PFBA) in human lungs and kidneys. The German Federal Institute for Risk Assessment (BfR) checked these results using a more precise quantification method. The result: Only one sample contained a quantifiable PFBA value of 0.17 nanograms (ng)
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Everyday exposure to obesity-promoting chemicals (obesogens) represents a significant risk to public health, and needs stronger regulation to minimize exposure and protect people’s health, according to evidence presented today at the 59th Annual European Society for Paediatric Endocrinology Meeting. Dr Leonardo Trasande is an internationally renowned leader in environmental health, who will draw together the
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When recovering from an addiction, managing cravings isn’t easy. Here, we share six key tips to help you through these unique challenges It’s normal for anyone who has an addictive behaviour to experience cravings, but that doesn’t make them any less frustrating. During the initial stages of recovery, they can be intense, but over time,
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Federal efforts to improve the quality, safety, and efficacy of over-the-counter sunscreens took a step forward today with the release of two orders aimed at updating regulatory requirements for most sunscreen products in the United States. “We see it as a key public health priority and our regulatory obligation to make sure that marketed sunscreen
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New reports reveal how much eating disorders are costing us in the UK and the amount being spent on research The coronavirus has taken its toll on our mental health as a nation over the last 18 months, affecting all of us in different ways. One area that has been hit particularly hard is eating
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The COVID-19 pandemic is far from over, but the official death toll has already surpassed the estimated fatalities from the 1918 influenza outbreak, making it the deadliest health crisis in recent American history.  Influenza Outbreak vs. COVID-19 Pandemic Johns Hopkins University reported on its website Monday that the deaths in the country due to COVID-19
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The US Food and Drug Administration (FDA) has approved evolocumab (Repatha, Amgen), a PCSK9 inhibitor, for use as add-on treatment to diet alone or with other therapies for children 10 years of age and older with either heterozygous or homozygous familial hypercholesterolemia (FH).  Approval was based on randomized trials of evolocumab in both types of
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Developing the advanced and powerful detection techniques to characterize as many endocrine disruptors as possible with ultra-sensitivity in the environment is still challenging, however highly demanded. Environmental estrogens (EEs), as typical endocrine disruptors, have been listed as one of the global environmental issues to be addressed through international collaboration by the United Nations. They are
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Theranos founder Elizabeth Holmes and her partner Billy Evans leaves the Robert F. Peckham U.S. Courthouse after the delivery of opening arguments in her trial, in San Jose, California, September 8, 2021. Peter DaSilva | Reuters SAN JOSE, CALIF – A former lab director at Theranos testified on Friday that he thought the blood-testing start-up
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More than half of all practicing physicians show signs of burnout, studies show. Contemporary physicians face tremendous pressures due to a confluence of factors, including balancing heavy patient loads within constrained schedules, the increasing complexity of health problems, and burdensome COVID-related documentation requirements. These circumstances — and more — challenge physician empathy, and even to
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Results from a 10-year study of children and adolescents who underwent a common weight loss operation to treat severe obesity show they safely have long-lasting major weight loss and improvement of their obesity-related medical problems without stunting their growth in height. The study, involving the longest known follow-up of pediatric patients after laparoscopic sleeve gastrectomy,
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Diagnostic accuracy of confocal laser endomicroscopy (CLE) was too low to identify wheat sensitivities in non-celiac irritable bowel syndrome (IBS) patients, according to a prospective multicenter study. The method accurately detected wheat sensitivity in only about half of the individuals who responded to a gluten-free diet at 2 months (51.4% sensitivity, 97.5% CI 38.7-63.9%), reported
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