Call for Resistance to E-Cigs; Optimal Timing of ADT; Include Diet in Cancer Therapy

The American Association for Cancer Research and the American Society of Clinical Oncology adopted a joint policy statement calling for continued policy and regulatory efforts to combat the use of electronic nicotine delivery systems (ENDS), such as e-cigarettes, as well as support for research into the health effects of ENDS.

The FDA issued marketing denial orders for Logic Technology Development’s Pro Menthol e-Liquid Package and Power Menthol e-Liquid Package after concluding the products do not meet current public health standards.

An analysis of 7,000 men with prostate cancer treated in 12 randomized trials showed that beginning androgen deprivation therapy (ADT) at the same time as radiation therapy provides optimal results. (UCLA Jonsson Comprehensive Cancer Center, Journal of Clinical Oncology)

Singer Carly Simon paid tribute to her two sisters, who died of cancer one day apart. (CNN)

Continuing on a downward trend, yearly cancer death rates dropped by 2.1% from 2015 to 2019, with the steepest drops seen for lung cancer and melanoma. There was also an increase in pancreatic cancer survival, according to the National Cancer Institute’s latest annual report to the nation.

Alpine Immune Sciences announced it has voluntarily terminated enrollment in two clinical trials of the CD28 co-stimulator/dual checkpoint inhibitor davoceticept after a second patient death.

AstraZeneca announced that the AKT inhibitor capivasertib plus fulvestrant resulted in “statistically significant and clinically meaningful” improvement in progression-free survival (PFS) versus fulvestrant alone in a phase III trial for patients with advanced/metastatic hormone receptor-positive breast cancer.

In a separate announcement, AstraZeneca reported that its next-generation selective estrogen receptor degrader camizestrant significantly improved PFS versus fulvestrant in a phase II randomized trial involving patients with advanced estrogen receptor-positive breast cancer.

Participants in an international congress on diet and cancer concluded that dietary interventions, such as intermittent fasting, should be incorporated into treatment strategies for cancer. (CNIO)

A new production process has reduced processing time for CAR T cells from 8 days to 1. (University Hospitals Seidman Cancer Center)

Studies involving preclinical models suggested that circadian rhythm disruption, such as sleep disturbance or shift work, can trigger a gene involved in cancer development. (University of Rochester)