The genomic landscape of circulating tumor DNA (ctDNA) was comparable to the landscape of tissue biopsies in a large study of patients with metastatic castration-resistant prostate cancer (mCRPC), according to researchers. The type and frequency of genomic alterations observed were largely similar in ctDNA and tissue, and there was high concordance for BRCA1/2 alterations. Comprehensive
Cabozantinib (Cabometyx) came out on top as upfront therapy in metastatic papillary renal cell carcinoma (RCC) in a randomized phase II study. Treatment with the multikinase inhibitor yielded a median progression-free survival (PFS) of 9.0 months, as compared to 5.6 months with sunitinib (Sutent), which has been the default standard of care in this setting
The COVID-19 Pandemic has brought great instability to the job market and, as a result, a large number of folks have lost their insurance due to losing their jobs. Today, February 15th, the Healthcare Marketplace, healthcare.gov, will reopen for a three-month special enrollment period. This means that if you do not have insurance OR want
Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. At a time when COVID-19 vaccination efforts have been hampered by a lack of coordination and overwhelmed by public demand, Google is entering the fray to try and help states and localities better organize and focus their initiatives with cloud-based analytic,
Around 17 new cases of liver cancer are diagnosed every day in the UK. There are many risk factors associated with developing liver cancer. Two of these are age and damage to the liver, with both affecting our immune system. When it comes to staying healthy, exercise is often suggested as one of the tools
Diagnostic testing, contact tracing, and the isolation of infected individuals and their contacts form the foundation of managing the current coronavirus disease 2019 (COVID-19) pandemic. Moreover, the number of positive tests is a key measure of the severity of the outbreak at regional, national, and international levels. The true number of infections with the severe
A medic holds Covid-19 vaccine Covaxin vials during the countrywide inoculation drive, in Jaipur, Rajasthan, India, Saturday, Feb. 6, 2021. Vishal Bhatnagar | NurPhoto | Getty Images India could become the world’s second largest Covid vaccine maker, and analysts say the country has the capacity to produce for both its own population and other developing
Children treated for cancer with approaches such as chemotherapy can develop therapy-related myeloid neoplasms (a second type of cancer) with a dismal prognosis. Scientists at St. Jude Children’s Research Hospital have characterized the genomic abnormalities of 84 such myeloid neoplasms, with potential implications for early interventions to stop the disease. A paper detailing the work
The significant role and impact of structural racism needs to be considered in racial and ethnic health-disparities research, say the editors of the American Heart Association (AHA) journal Circulation: Cardiovascular Quality and Outcomes. The statement — The Groundwater of Racial and Ethnic Disparities Research: A Statement from Circulation: Cardiovascular Quality and Outcomes — was published
Pembrolizumab (Keytruda) plus lenvatinib (Lenvima) improved survival outcomes and response rates as a first-line treatment for advanced renal cell carcinoma (RCC), the randomized phase III CLEAR study showed. For the primary endpoint, median progression-free survival (PFS) reached a whopping 23.9 months with the anti-PD-1 immunotherapy plus VEGFR tyrosine kinase inhibitor (TKI) combination, as compared with
Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Two of the nation’s top federal health agencies asked Maryland officials for help in bolstering their supplies of COVID-19 vaccines for their staff, underscoring the challenges of the vaccines’ initial rollout. Maryland Gov. Larry Hogan, a Republican, said he is seeking
This content originally appeared on Beyond Type 1. Republished with permission. By Stacey Simms Stacey: Tell me more about T1detect. Frank: T1Detect is an education and awareness program about type 1 diabetes(T1D) and its risks, and a very important component of that is making the [autoantibodies] test available to people. Because right now, they’re not
5 February 2021 — The KESTREL Phase III trial for AstraZeneca’s Imfinzi (durvalumab) did not meet the primary endpoint of improving overall survival (OS) versus the EXTREME treatment regimen (chemotherapy plus cetuximab), a standard of care, in the 1st-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) whose tumours
If voicing your thoughts and emotions out loud feels intimidating, why not try therapeutic writing, which could do wonders for your mental health? There are many ways that the arts can guide us through difficult times – one of which is through therapeutic writing. You don’t need an English degree, to be the next Shakespeare,
Dr. Virginia Banks, an infectious disease specialist, is part of a group of Black physicians and scientists who are focused on ways to solve health-care disparities. Dr. Virginia Banks Dr. Virginia Banks says if the U.S. really wants to bring the pandemic to an end, it’s going to take mobile vans of vaccines in neighborhoods
Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this medication, but until now, studies have been too small and too varied to accurately characterize this risk. Today in The Lancet Child & Adolescent Health, investigators at
Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The CDC on Friday released long-awaited guidance for how public K-12 schools in the United States should reopen, and advice on what to do to stay that way. The 35-page document makes clear the Biden administration’s position: “It is critical for
Anti-PD-1 immunotherapy after radical surgery in high-risk muscle-invasive urothelial cancer improved disease-free survival (DFS), regardless of PD-L1 status, a randomized phase III trial showed. In the intent-to-treat (ITT) population of the CheckMate 274 study, DFS reached 21 months in patients who received nivolumab (Opdivo) versus 10.9 months for those assigned to placebo (HR 0.70, 98.31%
One out of every four American children is currently struggling with food insecurity. During the pandemic, job losses and other financial tragedies have caused thousands of families not to be able to afford food, many for the first time. The burden on food banks and pantries has been increasing quickly. These organizations are straining under
For lovers of music, theater, and art, 2020 was a lost year. From March onward, it became clear that the public health risks posed by the Covid-19 pandemic were too great– large gatherings, whether for concerts, conventions, or other types of festivals– couldn’t go on. One year later, many countries still find the situation unchanged.
Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Long-term COVID-19 recovery, aka COVID “long-hauler” syndrome, continues to challenge both clinicians and patients, with evidence on how best to manage the most common symptoms based primarily on cross-sectional studies and anecdotal reports. Until a clearer picture emerges from larger, prospective, and multicenter studies,
This content originally appeared on ForGoodMeasure. Republished with permission. In my humble opinion, picnics are ubiquitous with summer & no al fresco dining experience is complete without crisp, crunchy vegetables & an accompanying dip. Here’s one of our favorites. A simplified version of Greek Ktipiti, this recipe combines the briny tang of fresh feta with
Using publicly available coronavirus disease 2019 (COVID-19) data from Israel, a study suggests the BioNTech-Pfizer BNT162b2 vaccine is proving highly effective in the real world. Several vaccines have now been approved for COVID-19, and many countries have started intensive vaccination programs. In Israel, vaccination started on December 20, 2020. By the end of January, 33%
FDA Approves Evkeeza (evinacumab-dgnb) for Patients with Homozygous Familial Hypercholesterolemia TARRYTOWN, N.Y., Feb. 11, 2021 /PRNewswire/ — Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) approved Evkeeza (evinacumab-dgnb) as an adjunct to other low-density lipoprotein cholesterol (LDL-C) lowering therapies to treat adult and pediatric patients aged 12 years
Learn how to discover you and your partner’s love languages, and unlock a whole new level of communication Communication – we all know it’s one of the key factors in a healthy, happy relationship. But, when it comes to expressing love, what happens if you’re speaking entirely different languages? The concept of “love languages” comes
Reopening indoor dining is “an extraordinarily reckless and premature decision” as new, more infectious variants of the coronavirus spread in the U.S., virologist Angela Rasmussen told CNBC Friday. Indoor dining resumed at a limited capacity in New York and Portland, Oregon, on Friday. “While I appreciate the economic importance of opening businesses back up and
In an effort to help schools reduce the risk of COVID-19 outbreaks as they resume in-person instruction, University of California San Diego and the County of San Diego are testing the Safer at School Early Alert system, an evidence-informed program to detect SARS-CoV-2 at schools and child care centers. Modeled after UC San Diego’s Return
In 1978, students attending the Berkeley campus of the University of California decided Valentine’s Day needed to go, and Condom Day, more precisely, Condom Week, should take its place. In the ensuing years, the month of February became National Condom Month. The point: to promote safer sex via educational events in an effort to raise