Clinical Trials & Research

A Phase 1 clinical trial of a novel influenza vaccine has begun inoculating healthy adult volunteers at the National Institutes of Health Clinical Center in Bethesda, Maryland. The placebo-controlled trial will test the safety of a candidate vaccine, BPL-1357, and its ability to prompt immune responses. The vaccine candidate was developed by researchers at the

Scientists are constantly seeking to improve the efficiency of the delivery of biologically active particles to the body tissue, using novel vehicles and adjuvants. Study: Lipid-peptide nanocomplexes for mRNA delivery in vitro and in vivo. Image Credit: remotevfx.com/Shutterstock A new paper published in the Journal of Controlled Release reports the methodical development of lipid-peptide nanocomplexes as a

Tau hyperphosphorylation is the key characteristic pathological hallmarks of Alzheimer’s disease (AD). Recently studies showed periodontitis and periodontal pathogen are significant risk factors for AD. Treponema denticola (T. denticola), as the main periodontal pathogen of periodontitis, has been reported a possible link with AD, however, the role of T. denticola in AD pathogenesis is still

Smartphone apps that use artificial intelligence (AI) to spot skin cancer are endangering the public, many of whom trust that these apps are safe to use, experts at the British Association of Dermatologists (BAD) have warned. This trust, along with a failure of many such apps to meet the appropriate regulatory standards, is putting users

As people around the world are learning to live with a new phase of the COVID-19 pandemic, researchers from UConn’s College of Agriculture, Health and Natural Resources, in collaboration with Spanish institutions, have learned valuable lessons about the role social media played during pandemic lockdowns. In a recently published study in the International Journal of

Today, CDC Director Rochelle P. Walensky, M.D., M.P.H., endorsed the Advisory Committee on Immunization Practices’ (ACIP) recommendation that all children 6 months through 5 years of age should receive a COVID-19 vaccine. This expands eligibility for vaccination to nearly 20 million additional children and means that all Americans ages 6 months and older are now

Susan G. Komen®, the world’s leading breast cancer organization, is awarding $21.7 million to fund 48 new research projects at 26 distinguished academic medical institutions in the U.S. that are focused on improving patient outcomes – particularly for people with the most aggressive breast cancers, or who have experienced a recurrence or metastasis. With this

Results from one of the largest global studies of atrial fibrillation (AFib) procedures show that the simple approach is usually best when it comes to ablation, a procedure where physicians destroy or ablate cardiac tissue to correct irregular heart rhythms. The findings could change the way patients are treated for AFib. Researchers from Tulane University

Rates of melanoma, a deadly form of skin cancer, are on the rise in Canada. Those living in southern and coastal areas are most at risk, according to a new study led by McGill University. Cutaneous melanoma causes more deaths than any other skin cancer, accounting for 1.9 per cent of all cancer deaths in

A CDC investigation notice regarding multistate outbreaks of Salmonella infections has been posted: https://www.cdc.gov/salmonella/backyardpoultry-06-22/index.html Key points: CDC and public health officials in several states are investigating multistate outbreaks of Salmonella infections linked to contact with backyard poultry. In total, 219 illnesses have been reported from 38 states, and 27 people have been hospitalized. One in

A new perspective by researchers from the American Cancer Society (ACS) and the University of Texas Health Science Center at San Antonio shows the high burden of breast cancer mortality in African American (Black) women versus White women began in the United States in the 1980’s. At that time, breast cancer screening (mammography) and treatments

Bottom Line: The accuracy of diagnostic mammograms differed across racial and ethnic groups, with variation in several measures of diagnostic performance. Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. Authors: Sarah J. Nyante, PhD, associate professor of radiology at the University of

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a major blip in the health, societal and economic well-being of the whole world for more than two years, following its unexpected emergence in December 2019. This beta-coronavirus undergoes transcription in the host cell, giving rise to multiple polyproteins that are cleaved by viral proteases to

Having shown that diet can influence gene expression, science is starting to find out more about how this happens. According to an article recently published in Food and Chemical Toxicology, a diet supplemented with or deficient in methionine, an essential amino acid abundant in eggs, meat and seafood, affects the expression of genes associated with

Thought LeadersHenry FingerhutSenior Policy Analyst for Science & InnovationTony Blair Institute for Global Change In this interview, News-Medical speaks to Henry Fingerhut, Senior Policy Analyst for Science & Innovation at the Tony Blair Institute for Global Change, about genomic surveillance and its associated opportunities and challenges. In collaboration with Professor Derrick Crook of Oxford’s Nuffield

Researchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis. The results are published in Nature Chemical Biology. Our findings indicate a new potential target for treating diabetes, in that

Monkeypox virus is a completely different virus than the viruses that cause COVID-19 or measles. It is not known to linger in the air and is not transmitted during short periods of shared airspace. Monkeypox spreads through direct contact with body fluids or sores on the body of someone who has monkeypox, or with direct

How do cancer cells differ from healthy cells? A new machine learning algorithm called “ikarus” knows the answer, reports a team led by MDC bioinformatician Altuna Akalin in the journal Genome Biology. The AI program has found a gene signature characteristic of tumors. When it comes to identifying patterns in mountains of data, human beings

Women in rural and regional areas recovering from gynecological cancer and treatment will now have access to a University of Queensland rehabilitation program through telehealth. Professor Sandie McCarthy from UQ’s School of Nursing, Midwifery and Social Work, and co-lead of Mater Research’s Health Care Delivery and Innovation program, said additional funding from Wesley Medical Research

When accounting for miles traveled during biking, walking, or driving, Black and Hispanic Americans experience higher motor vehicle-related death rates than White Americans or Asian Americans. In 2021, nearly 43,000 people died in motor vehicle-related crashes in the United States—the highest number of US traffic fatalities since 2005, and more than a 10 percent increase

Albert Einstein College of Medicine researchers have been awarded a five-year, $3.5 million grant from the National Institutes of Health (NIH) to study the effects of COVID-19 on the brains of adults who had mild or asymptomatic infection. Using neuroimaging, cognitive, and immunological tests, the investigators will examine if SARS-CoV-2 infection induces lasting changes in

Momelotinib, an oral pill taken once a day, significantly improved outcomes of patients treated for myelofibrosis (MF), a rare but fatal bone marrow cancer, researchers reported June 7. Ruben Mesa, MD, FACP, executive director of the Mays Cancer Center, home to UT Health San Antonio MD Anderson Cancer Center, presented results of the MOMENTUM phase

Jun 6 2022 Scientific Laboratory Supplies (SLS) – the leading supplier of equipment, chemicals and consumables for laboratory use in the UK – has announced the acquisition of two businesses, Gem Scientific and Northern Balance, to expand its product and service offerings. Both companies will continue to operate as independent entities and retain all employees,

Aqueous droplet formation by liquid-liquid phase separation (or coacervation) in macromolecules is a hot topic in life sciences research. Of these various macromolecules that form droplets, DNA is quite interesting because it is predictable and programmable, which are qualities useful in nanotechnology. Recently, the programmability of DNA was used to construct and regulate DNA droplets

In a study of patients with high-risk renal cell carcinoma, those who took the drug everolimus daily for up to one year after surgery lived longer without their disease returning (recurrence-free survival, or RFS) than those who did not take everolimus, although the results narrowly missed the clinical trial’s prespecified level for statistical significance. Improvement

A new study posted on the medRxiv* preprint server found that despite a lower coronavirus disease 2019 (COVID-19) vaccine efficacy against reinfection with the Omicron variant, these vaccines demonstrate a marked efficacy against reinfection with severe acute respiratory coronavirus 2 (SARS-CoV-2) Alpha and Delta variants, as well as the Omicron variant––lasting up to nine months,

In a recent study published in Emerging Infectious Diseases, researchers evaluated the increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among university students immediately after returning to their university in September 2020. The students relocated to their universities for the new academic term during the coronavirus disease 2019 (COVID-19) pandemic in England. Study:

Since April 2020, various international reports have identified a rare but dangerous multisystem inflammatory disease in children infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some of the most common symptoms associated with this disease included fever, hyper-inflammation, a Kawasaki Disease (KD)-like presentation, as well as a shock-like condition that overlaps with toxic