Clinical Trials & Research

What fathers eat has a lasting effect on the future health of their unborn children, new research has revealed. The Queensland Family Cohort study, led by The University of Queensland and Mater Research, identified an urgent need for targeted public health messaging to improve the diets of soon-to-be parents. The researchers examined dietary data from

Patients taking renin-angiotensin-aldosterone system inhibitor (RAASi) medications for heart failure had significantly lower blood potassium levels when taking patiromer—a drug that helps to prevent the body from absorbing too much potassium—compared with a placebo, in a study presented at the American College of Cardiology’s 71st Annual Scientific Session. The results suggest patiromer, which binds to

Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in Black Americans, according to a new study at the University of Mississippi Medical Center in Jackson. John S. Clemmer, PhD, a physiologist and lead author of the study, said his team model used a calcium channel blocker to

In a paper in the journal Nature, Los Alamos National Laboratory scientists Bette Korber, Hyejin Yoon, Will Fischer and James Theiler, among nearly 130 authors from institutions around the world, describe their groundbreaking collaborative work, “Defining the risk of SARS-CoV-2 variants on immune protection.” Korber, Fischer, Yoon and Theiler are members of a rarified team

In a recent Viruses review, researchers discuss the evolution and mechanisms of mutations that have occurred in the spike (S) protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Mutations and Evolution of the SARS-CoV-2 Spike Protein. Image Credit: sanjaya viraj bandara / Shutterstock.com The SARS-CoV-2 S protein The SARS-CoV-2 S protein is the

Acute myeloid leukemia (AML) remains harder to treat therapeutically due to the high existing genetic heterogeneity not only between patients but also between the population of subclones of cancer cells within the same person. Despite the knowledge advances, understanding the metabolic characteristics of altered cells in this pathology is one of the scientific challenges for

To create a safer learning environment for Black students, schools should turn to culturally relevant and Afrocentric policies and practices that better incorporate their identity in the school culture, according to a new University at Buffalo-led study. The research, published earlier this year in School Psychology International, suggested that practices such as allowing Black students

Revving up a process that slows down as we age may protect against atherosclerosis, a major cause of heart attacks and strokes. In findings published online today in Proceedings of the National Academy of Sciences (PNAS), scientists at Albert Einstein College of Medicine led by Ana Maria Cuervo, M.D., Ph.D., successfully minimized artery-narrowing plaque in

Many issues regarding the coronavirus disease 2019 (COVID-19), including its prognosis, management, and interactions with the immune system, as well as the evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remain unanswered. One highly vulnerable patient population to the severe effects of COVID-19 includes pregnant mothers. Study: Anti-SARS-CoV-2 IgA and IgG in Human Milk

Our bowels accommodate billions of active microbes that affect the health, a fact that is arousing increasing interest also among athletes. For example, performance-enhancing intestinal microbe populations have been found in athletes participating in endurance sports. There is also research evidence for the notion that physical activity produces health-promoting changes in the bowels. Sanna Lensu

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the impact of mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of interest (VOI) and variants of concern (VOC) on the properties of the cluster of differentiation 8 (CD8) T lymphocytes. Study: In silico analysis predicts a limited impact of

Researchers at the George Washington University published findings from the world’s largest cohort study showing that hospitalized patients with moderate COVID-19 who were given aspirin early on in their treatment had a lower risk of dying compared to patients who were not given aspirin. This is our third study and the culmination of 15 months

Despite recent efforts to improve women’s leadership in cardiovascular clinical trial research over the last decade, the number of female principal investigators (PIs) still falls well below the number of males leading similar heart studies, according to a study presented at the American College of Cardiology’s 71st Annual Scientific Session. I was rather surprised that

Scientists have worked extensively hard to contain the coronavirus disease (COVID-19) pandemic caused by the rapid transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). They developed diagnostic kits for rapid detection of the virus and developed many pharmaceutical and non-pharmaceutical means to reduce transmission of the virus as well as the mortality rate. Study: From

Genetic testing of saliva samples identifies the SARS-CoV-2 virus more quickly than testing of nasal swabs. The research is published March 21 in Microbiology Spectrum, a journal of the American Society for Microbiology. “That is important because people can spread COVID-19 before they know that they have it,” said coauthor Donald K. Milton, M.D., DrPH,

An investigation into how human nerve cells differ from animal cells has provided researchers from The University of Texas at Dallas’ Center for Advanced Pain Studies (CAPS) with important clues in the pursuit of more effective treatments for chronic pain. Dr. Ted Price BS’97, Ashbel Smith Professor of neuroscience in the School of Behavioral and

In a study led by Cedars-Sinai, researchers have uncovered new information about how the area of the brain responsible for memory is triggered when the eyes come to rest on a face versus another object or image. Their findings, published in the peer-reviewed journal Science Advances, add to scientific understanding of how memory works, and

Numerous variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the initial Wuhan-Hu-1 prototype. The new variants evade pre-existing immunity by prompting a different antibody response than the prior variants. Study: The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes. Image Credit: Adao/Shutterstock Acknowledgment

Scientists at Yale Cancer Center have discovered new consequences of specific gene mutations that play a role in the development of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Approximately half the patients diagnosed with MDS and 10% of patients with AML are found to have splicing factor mutations leading to ineffective blood cell production

In a recent study published in Biology* researchers determined the immune signature of the multisystem inflammatory syndrome in children (MIS‐C) among hospitalized children diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Study: Hemophagocytic Lymphohistiocytosis Gene Variants in Multisystem Inflammatory Syndrome in Children. Image Credit: Bernard Chantal/Shutterstock MIS-C is a rare and delayed complication

Historically, the neurological mechanisms underlying sleep-cycle generation have been elusive. But now, researchers from Japan have uncovered new information about how the brain transitions from one sleep state to another. In a study published this month in Science, researchers from the University of Tsukuba have revealed that a temporary increase in dopamine levels in the

Exposure to ozone from air pollution has been linked to an increase in depressive symptoms for adolescents over time, even in neighborhoods that meet air quality standards, according to new research published by the American Psychological Association. Ozone is a gas that is produced when various pollutants from motor vehicle exhaust, power plants and other

In a paper published today in Sciences Advances, researchers in the Department of Chemistry and the Department of Physics & Astronomy at the University of California, Irvine revealed new details about a key enzyme that makes DNA sequencing possible. The finding is a leap forward into the era of personalized medicine when doctors will be

Home-based, self-administered tests for influenza are comparable in accuracy to rapid diagnostic tests in clinical settings, according to a recently published, peer-reviewed study. Home tests are a valuable tool to support the management of influenza and other respiratory infections.” Matthew J. Thompson, professor of global health and family medicine, University of Washington School of Medicine,

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) mutations on antiviral restriction mediated by interferon-induced transmembrane (IFITMs) proteins and guanylate binding proteins (GBPs). Study:SARS-CoV-2 Spike evolution influences GBP and IFITM sensitivity. Image Credit: MattLphotography/Shutterstock The interferon-stimulated genes (ISGs), components

Professor Charles Ramassamy and his postdoctoral researcher Mohamed Haddad at Institut national de la recherche scientifique (INRS), in collaboration with scientists from Université de Montréal, McGill University, and Université du Québec à Montréal (UQAM), believe that tannic acid plays a role in inhibiting three important molecular pathways involved in the SARS-CoV-2 infection. Their work was

A medium-chain fatty acid found in energy drinks might one day help protect against heart attack injuries. “Heart attacks are still a leading cause of death worldwide, that often come with devastating complications,” said Zhong Wang, Ph.D., an associate professor of cardiac surgery at the University of Michigan Frankel Cardiovascular Center, who is the senior

EKF Diagnostics Holdings plc (AIM: EKF), the AIM-listed global diagnostics business, announces that EKF Life Sciences, a division of EKF which manufactures diagnostics enzymes and contracted custom products for use in medical diagnostics, pharmaceutical and industry, has signed a  partnership agreement (the “Agreement”) with ABEC, Inc (“ABEC”), a leading global provider of engineered solutions and services for