Clinical Trials & Research

A team led by scientists at Baylor College of Medicine uncovered new evidence supporting a cancer-promoting role for enzyme MAPK6. The study, published in the journal Science Advances, shows that MAPK6 furthers cancer growth by activating the AKT pathway, a known cancer-promoting cellular mechanism. The findings suggest that therapies directed at interfering with MAPK6 activity

Immune checkpoint inhibitors are a type of cancer treatment that help the immune system’s T cells recognize and attack tumors. But these immunotherapy drugs aren’t effective against all cancers. In a study published today in Science Advances, University of Pittsburgh and UPMC researchers reveal how certain cells drive immunotherapy resistance in a mouse model of

Regular blood tests before and during chemotherapy for prostate cancer can detect whether or not a patient is resistant or developing resistance to treatment with docetaxel, according to research presented at the NCRI Festival. The findings could enable doctors to detect early on, without invasive procedures, if a treatment is working and switch to alternatives

Studies have shown that mortality rates in hospitalized patients with COVID-19 are high, ranging between 10% and 30%. REGEN-COV®, a combination of monoclonal antibodies casirivimab and imdevimab, is approved in the United States and other regions for emergency treatment of COVID-19 outpatients with mild to moderate SARS-CoV-2 infection and post-exposure prophylaxis. REGEN-COV has been shown

Recent observations show that the effectiveness of COVID-19 vaccines has decreased because of the emergence of the Delta variant and the waning of vaccine-induced immunity. This has led to a campaign in many countries to provide booster doses of COVID-19 vaccines. A register-based cohort study of the effectiveness of COVID-19 vaccines was performed to help

Healthcare workers and people they live with are at an increased risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Hospital healthcare workers (HCWs) worldwide have been found to have a higher number of SARS-CoV-2 infections and higher antibody seroprevalence compared to the general population. A thorough understanding of SARS-CoV-2 transmission and potential

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for the coronavirus disease 2019 (COVID-19), is a novel coronavirus in the genus Betacoronavirus that was first identified in Wuhan, China toward the end of 2019. SARS-CoV-2 continues to evolve with growing concern for the emergence of new variants. Thus far, SARS-CoV-2

Scientists at the Francis Crick Institute have found how the immune system triggers an ’emergency’ dendritic cell response during infection, with dendritic cells at the site of infection being reinforced by new cells which travel from the bone marrow. Dendritic cells have an important role in the immune system, detecting infectious bacteria, fungi or viruses

Earlier this year, the World Health Organization announced a global campaign to combat ageism — discrimination against older adults that is pervasive and harmful but often unrecognized. “We must change the narrative around age and ageing” and “adopt strategies to counter” ageist attitudes and behaviors, WHO concluded in a major report accompanying the campaign. Several

The antiviral Lagevrio (molnupiravir) is safe and effective at reducing the risk of hospitalization and death in people with mild to moderate COVID-19 who are at increased risk of developing severe disease, the Medicines and Healthcare products Regulatory Agency (MHRA) announced today. This follows a rigorous review of its safety, quality and effectiveness by the

Some spent an extra hour a day on chores and childcare during lockdowns, while others got an added daily hour of solo leisure time – and most of us reduced time spent on paid work by around half an hour a day. This is according to a new study of “time-use diaries” kept by 766

New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that a virtual exercise program can be safe for people with musculoskeletal conditions, improved their health outcomes, and helped them feel more socially connected, an important benefit during the pandemic when many people have chosen to avoid in-person exercise

A nationwide study of over 1 million births in the English National Health Service (NHS) between 2015 and 2017, published in The Lancet, has found large inequalities in pregnancy outcomes between ethnic and socioeconomic groups in England. The findings suggest that current national programs to make pregnancy safer, which focus on individual women’s risk and

The spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over the whole world, causing successive waves of coronavirus disease 2019 (COVID-19), has led to intensive research into SARS-CoV-2, as well as its detection and treatment. Among the most important threads has been the need to detect new and emerging SARS-CoV-2 variants, since these

Researchers at Washington University School of Medicine in St. Louis have received a grant to develop the next generation of personal protective equipment (PPE) for combat troops. Harnessing the genetics of hookworms, the research is focused on developing “living factories” that produce antibodies and anti-nerve agents to protect against chemical and biological weapons. Combat troops

Oct 29 2021 Johns Hopkins Children’s Center brought Halloween to pediatric patients today with its annual celebration. During this year’s festivities, about 50 staff members from both adult and pediatric units around the Children’s Center and The Johns Hopkins Hospital dressed in costumes and visited pediatric inpatient units to share special treats with patients. Dozens

Strategically increasing testing capacity, either by making diagnostic tests faster or more available, can reduce reliance on costly preventative interventions, such as distancing and shutdowns, according to a team of researchers led by Penn State. The team designed its mathematical model to support government and public health officials in implementing testing and isolation programs to

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constantly mutating. As of now, several different distinct SARS-CoV-2 lineages have arisen in multiple geographic areas around the world. In a recently published Nature Communications study, the authors describe the B.1.620 lineage discovered in Lithuania. According to this study, the lineage is inferred to have originated

Researchers from The University of Texas at San Antonio College for Health, Community and Policy (HCaP) have conducted a study that could be key to decreasing maternal mortality rates in the U.S. UTSA Associate Professor of Public Health Jeffrey Howard, Associate Professor of Demography Corey Sparks and doctoral candidate in demography Samson Olowolaju, in collaboration

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Peking University and Zhujiang Hospital of Southern Medical University have developed a ferritin (Fn)-based nanomedicine for targeted delivery of arsenic (As) and efficient therapy against diverse leukemia types. The study was published in Nature Nanotechnology on Oct. 25. Leukemia is a

The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 initially emerged from Wuhan, China, in late December 2019, and has since caused large-scale global outbreaks and over 4.9 million fatalities worldwide. Study: Targeting SARS‐CoV‐2 with Chaga mushroom: An in silico study toward developing a natural antiviral

A University of California, Irvine-led study suggests that the glucosyltransferase domain (GTD) is an ideal molecular target for therapeutic interventions for Clostridioides difficile infection (CDI). These findings may lead to new treatments to fight this deadly disease. Based on their findings that established the structural basis for Toxin B recognition of the small GTPases Rho

The World Health Organization and partners have issued an urgent call for concrete action to better protect health and care workers worldwide from COVID-19 and other health issues. The organizations are concerned that large numbers of health and care workers have died from COVID-19, but also that an increasing proportion of the workforce are suffering

What are the benefits of buffer exchange and what are the benefits of performing this work? Buffer exchange is the process of transferring a large biomolecule from one solution to another. It can be a chore and is often a source of processing error, but it is a task that must be completed to keep

A recent review describes the role of nanobodies as a new class of recombinant antibodies that are used in the treatment of the coronavirus disease 2019 (COVID-19). Study: The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization. Image Credit: Huen Structure Bio / Shutterstock.com Introduction To date, there are limited effective treatments available for

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread with rapid devastation throughout the world. The inability to contain its spread without resorting to draconian restrictions on ordinary social interactions and travel showed the urgent need for broad-spectrum antiviral drugs to combat the virus. Study: Efficient

A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia. In addition, in a subgroup of patients who required high-flow oxygen, investigators found that interferon beta-1a was associated with more adverse events and worse outcomes.

As part of its commitment to enhance access to high-quality care, NYU Langone Health has opened NYU Langone Ambulatory Care Bethpage—one of Nassau County’s largest multispecialty care centers—at 185 Central Avenue. “Our presence on Long Island continues to grow with the opening of an expansive care center in Bethpage,” says Andrew Rubin, senior vice president