Clinical Trials & Research

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for the coronavirus disease 2019 (COVID-19), is a novel coronavirus in the genus Betacoronavirus that was first identified in Wuhan, China toward the end of 2019. SARS-CoV-2 continues to evolve with growing concern for the emergence of new variants. Thus far, SARS-CoV-2
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Scientists at the Francis Crick Institute have found how the immune system triggers an ’emergency’ dendritic cell response during infection, with dendritic cells at the site of infection being reinforced by new cells which travel from the bone marrow. Dendritic cells have an important role in the immune system, detecting infectious bacteria, fungi or viruses
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Earlier this year, the World Health Organization announced a global campaign to combat ageism — discrimination against older adults that is pervasive and harmful but often unrecognized. “We must change the narrative around age and ageing” and “adopt strategies to counter” ageist attitudes and behaviors, WHO concluded in a major report accompanying the campaign. Several
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The antiviral Lagevrio (molnupiravir) is safe and effective at reducing the risk of hospitalization and death in people with mild to moderate COVID-19 who are at increased risk of developing severe disease, the Medicines and Healthcare products Regulatory Agency (MHRA) announced today. This follows a rigorous review of its safety, quality and effectiveness by the
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New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that a virtual exercise program can be safe for people with musculoskeletal conditions, improved their health outcomes, and helped them feel more socially connected, an important benefit during the pandemic when many people have chosen to avoid in-person exercise
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A nationwide study of over 1 million births in the English National Health Service (NHS) between 2015 and 2017, published in The Lancet, has found large inequalities in pregnancy outcomes between ethnic and socioeconomic groups in England. The findings suggest that current national programs to make pregnancy safer, which focus on individual women’s risk and
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The spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over the whole world, causing successive waves of coronavirus disease 2019 (COVID-19), has led to intensive research into SARS-CoV-2, as well as its detection and treatment. Among the most important threads has been the need to detect new and emerging SARS-CoV-2 variants, since these
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Researchers at Washington University School of Medicine in St. Louis have received a grant to develop the next generation of personal protective equipment (PPE) for combat troops. Harnessing the genetics of hookworms, the research is focused on developing “living factories” that produce antibodies and anti-nerve agents to protect against chemical and biological weapons. Combat troops
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Oct 29 2021 Johns Hopkins Children’s Center brought Halloween to pediatric patients today with its annual celebration. During this year’s festivities, about 50 staff members from both adult and pediatric units around the Children’s Center and The Johns Hopkins Hospital dressed in costumes and visited pediatric inpatient units to share special treats with patients. Dozens
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Strategically increasing testing capacity, either by making diagnostic tests faster or more available, can reduce reliance on costly preventative interventions, such as distancing and shutdowns, according to a team of researchers led by Penn State. The team designed its mathematical model to support government and public health officials in implementing testing and isolation programs to
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constantly mutating. As of now, several different distinct SARS-CoV-2 lineages have arisen in multiple geographic areas around the world. In a recently published Nature Communications study, the authors describe the B.1.620 lineage discovered in Lithuania. According to this study, the lineage is inferred to have originated
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Researchers from The University of Texas at San Antonio College for Health, Community and Policy (HCaP) have conducted a study that could be key to decreasing maternal mortality rates in the U.S. UTSA Associate Professor of Public Health Jeffrey Howard, Associate Professor of Demography Corey Sparks and doctoral candidate in demography Samson Olowolaju, in collaboration
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Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Peking University and Zhujiang Hospital of Southern Medical University have developed a ferritin (Fn)-based nanomedicine for targeted delivery of arsenic (As) and efficient therapy against diverse leukemia types. The study was published in Nature Nanotechnology on Oct. 25. Leukemia is a
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The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 initially emerged from Wuhan, China, in late December 2019, and has since caused large-scale global outbreaks and over 4.9 million fatalities worldwide. Study: Targeting SARS‐CoV‐2 with Chaga mushroom: An in silico study toward developing a natural antiviral
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A University of California, Irvine-led study suggests that the glucosyltransferase domain (GTD) is an ideal molecular target for therapeutic interventions for Clostridioides difficile infection (CDI). These findings may lead to new treatments to fight this deadly disease. Based on their findings that established the structural basis for Toxin B recognition of the small GTPases Rho
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The World Health Organization and partners have issued an urgent call for concrete action to better protect health and care workers worldwide from COVID-19 and other health issues. The organizations are concerned that large numbers of health and care workers have died from COVID-19, but also that an increasing proportion of the workforce are suffering
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A recent review describes the role of nanobodies as a new class of recombinant antibodies that are used in the treatment of the coronavirus disease 2019 (COVID-19). Study: The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization. Image Credit: Huen Structure Bio / Shutterstock.com Introduction To date, there are limited effective treatments available for
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The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread with rapid devastation throughout the world. The inability to contain its spread without resorting to draconian restrictions on ordinary social interactions and travel showed the urgent need for broad-spectrum antiviral drugs to combat the virus. Study: Efficient
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A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia. In addition, in a subgroup of patients who required high-flow oxygen, investigators found that interferon beta-1a was associated with more adverse events and worse outcomes.
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As part of its commitment to enhance access to high-quality care, NYU Langone Health has opened NYU Langone Ambulatory Care Bethpage—one of Nassau County’s largest multispecialty care centers—at 185 Central Avenue. “Our presence on Long Island continues to grow with the opening of an expansive care center in Bethpage,” says Andrew Rubin, senior vice president
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Counties that banned in-person religious gatherings and those with a greater number of hospitals per capita were associated with a decreased case-fatality rate of COVID-19 during the pandemic’s first wave, according to a new University of Michigan study. On the other hand, counties with high prevalence of asthma and a greater concentration of people over
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The newest Olympus DP series microscope camera—the DP23M monochrome camera—continues the series’ reputation for delivering high-quality images. With advanced features found on high-end microscope cameras, the DP23M monochrome camera provides premium fluorescence images at a reasonable cost. Image Credit: Olympus Fast, Efficient Fluorescence Protein Expression Checks The camera’s sensitive back side illuminated monochrome CMOS sensor,
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Researchers at Lund University in Sweden have developed a completely new stimulation method, using ultra-thin microelectrodes, to combat severe pain. This provides effective and personalized pain relief without the common side effects from pain relief drugs. The study, which was conducted on rats, has been published in the research journal Science Advances. The lack of
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Eating whole grain rye products instead of refined wheat alternatives can offer worthwhile health benefits. Researchers at Chalmers University of Technology, Sweden, recently published a study showing that people who ate high-fibre products made from whole grain rye lost more body fat and overall weight than those who ate corresponding products made from refined wheat.
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Children are not at risk for more severe COVID-19 disease with Delta compared to earlier severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, finds a new medRxiv* preprint study. In the first large-scale epidemiological study comparing SARS-CoV-2 infection between variants in children, researchers found children were more likely to be as sick from Delta as
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